Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times more active than PGE1 and more than 1000 times more active than its stable end product, 6-oxo-PGF1alpha. These results correlate well with the...

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Bibliographic Details
Published in:	Prostaglandins Vol. 13; no. 3; p. 389
Main Authors:	Tateson, J E, Moncada, S, Vane, J R
Format:	Journal Article
Language:	English
Published:	United States 01-03-1977
Subjects:	Arachidonic Acids - pharmacology Blood Platelets - metabolism Cyclic AMP - blood Dose-Response Relationship, Drug Humans Platelet Aggregation - drug effects Prostaglandins E - pharmacology Prostaglandins F - pharmacology
Online Access:	Get more information
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Summary:	Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times more active than PGE1 and more than 1000 times more active than its stable end product, 6-oxo-PGF1alpha. These results correlate well with the anti-aggregating activity of prostacyclin, compared with PGE1 and PGD2.
ISSN:	0090-6980
DOI:	10.1016/0090-6980(77)90019-3