The role of telomere biology in cancer

• Published in: Annual review of pathology Vol. 8; no. 1; pp. 49 - 78
• Main Authors: Xu, Lifeng, Li, Shang, Stohr, Bradley A
• Format: Journal Article
• Language: English
• Published: United States 24-01-2013
• Subjects: Animals; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Humans; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Telomerase - genetics; Telomerase - metabolism; Telomere - genetics; Telomere - metabolism; Telomere - physiology; Telomere Homeostasis
• ISSN: 1553-4006; 1553-4014
• DOI: 10.1146/annurev-pathol-020712-164030

Telomere biology plays a critical and complex role in the initiation and progression of cancer. Although telomere dysfunction resulting from replicative attrition constrains tumor growth by engaging DNA-damage signaling pathways, it can also promote tumorigenesis by causing oncogenic chromosomal rearrangements. Expression of the telomerase enzyme enables telomere-length homeostasis and allows tumor cells to escape the antiproliferative barrier posed by short telomeres. Telomeres and telomerase also function independently of one another. Recent work has suggested that telomerase promotes cell growth through pathways unrelated to telomere maintenance, and a subset of tumors elongate telomeres through telomerase-independent mechanisms. In an effort to exploit the integral link between telomere biology and cancer growth, investigators have developed several telomerase-based therapeutic strategies, which are currently in clinical trials. Here, we broadly review the state of the field with a particular focus on recent developments of interest.