Prevalence of antimicrobial resistance in Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Streptococcus pyogenes: results of a multicentre study in Turkey

• Published in: International journal of antimicrobial agents Vol. 19; no. 3; pp. 207 - 211
• Main Authors: Gür, Deniz, Özalp, Meral, Sümerkan, Bülent, Kaygusuz, Arif, Töreci, Kurtuluş, Köksal, İftihar, Över, Ufuk, Söyletir, Güner
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01-03-2002; Amsterdam Elsevier; New York, NY
• Subjects: Analysis. Health state; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial resistance; Biological and medical sciences; Drug Resistance, Bacterial; Epidemiology; General aspects; Haemophilus Infections - microbiology; Haemophilus influenzae; Haemophilus influenzae - drug effects; Humans; Medical sciences; Microbial Sensitivity Tests; Moraxella (Branhamella) catarrhalis - drug effects; Moraxella catarrhalis; Neisseriaceae Infections - microbiology; Pharmacology. Drug treatments; Pneumococcal Infections - microbiology; Public health. Hygiene; Public health. Hygiene-occupational medicine; Respiratory Tract Infections - microbiology; Streptococcal Infections - microbiology; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Streptococcus pyogenes; Streptococcus pyogenes - drug effects; Turkey; Asia; Turkey; Moraxella catarrhalis; Streptococcus pyogenes; Antimicrobial resistance; Haemophilus influenzae; Streptococcus pneumoniae; Human; Neisseriaceae; In vitro; Moraxella; Biological activity; Pasteurellaceae; Resistance; Streptococcaceae; Community acquired infection; Sensitivity resistance; Bacteria; Micrococcales; Antibacterial agent; Clinical isolate; Public health
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/S0924-8579(02)00003-1

The in vitro activities of several antimicrobial agents against clinical isolates of
Streptococcus pneumoniae (283),
Haemophilus influenzae (272),
Moraxella catarrhalis (179) and
Streptococcus pyogenes (256) were determined in a multicentre study with the participation of five hospitals from four cities in Turkey. Penicillin resistance in
S. pneumoniae was evaluated using the
E-test and the remaining agents by disk diffusion. For
S. pneumoniae overall 25.8% of the isolates were intermediately and 3.9% were highly resistant to penicillin and resistance to chloramphenicol, azithromycin and trimethoprim/sulphamethoxazole (TMP/SMX) was 3.8, 2.1 and 55.4%, respectively. Seven percent of
H. influenzae produced β-lactamase and all were susceptible to cefotaxime and azithromycin; the highest rate of resistance, 23.5%, was for TMP/SMX. Eighty-one percent of
M. catarrhalis isolates produced β-lactamase, 18.4% were resistant to TMP/SMX and all were susceptible to sulbactam/ampicillin combination. Resistance to chloramphenicol and azithromycin of
S. pyogenes was 2.2 and 1.9%, respectively.