Hantaviruses in Central South America: Phylogenetic analysis of the S segment from HPS cases in Paraná, Brazil

• Published in: Journal of medical virology Vol. 76; no. 4; pp. 553 - 562
• Main Authors: Raboni, Sonia M., Probst, Christian M., Bordignon, Juliano, Zeferino, Aurélio, dos Santos, Claudia N. Duarte
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-08-2005; Wiley-Liss
• Subjects: Biological and medical sciences; Brazil; Fundamental and applied biological sciences. Psychology; Genome, Viral; Hantavirus; Hantavirus - classification; Hantavirus - genetics; Hantavirus - isolation & purification; Hantavirus phylogeny; Hantavirus pulmonary syndrome; Hantavirus Pulmonary Syndrome - virology; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Microbiology; Miscellaneous; nucleocapsid; Phylogeny; Polymerase Chain Reaction; RNA, Complementary - genetics; RNA, Viral - genetics; S segment genomic sequence; Sequence Homology; Viral diseases; Viral Proteins - genetics; Virology; South America; Brazil; Central America; America; Virus; Bunyaviridae; Genomics; Nucleocapsid; Hantavirus; Phylogeny; Hantavirus phylogeny; Hantavirus pulmonary syndrome; S segment genomic sequence
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.20398

We sequenced the complete S segments of hantaviruses detected from 12 HPS patients living in southern of Brazil. Samples were obtained from patients diagnosed in different years, in distinct areas, and with a broad spectrum of clinical signs. Despite these differences, all the S proteins of hantavirus from Paraná were identical, except for one amino acid substitution. Phylogenetic analyses of the complete S segment nucleotide and amino acid sequences indicated that hantaviruses from Paraná form a distinct clade from those circulating in South and North America. Other hantaviruses from Brazil were not placed in the same clade. The Oligoryzomys nigripes‐associated strains ITA37 and ITA38 from Paraguay were found to belong to the same clade as the hantaviruses from Paraná. Paraguay and Paraná state are located at the same latitude and some ecosystems are similar in both places. The geographic position and common rodent hosts could explain this phylogenetic relationship. J. Med. Virol. 76:553–562, 2005. © 2005 Wiley‐Liss, Inc.