Sphincter-Sparing Local Excision and Adjuvant Radiation for Anal-Rectal Melanoma

• Published in: Journal of clinical oncology Vol. 20; no. 23; pp. 4555 - 4558
• Main Authors: BALLO, Matthew T, GERSHENWALD, Jeffrey E, ROSS, Merrick I, ZAGARS, Gunar K, LEE, Jeffrey E, MANSFIELD, Paul F, STROM, Eric A, BEDIKIAN, Agop Y, KIM, Kevin B. S, PAPADOPOULOS, Nicholas E, PRIETO, Victor G
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01-12-2002; Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Aged, 80 and over; Anus Neoplasms - pathology; Anus Neoplasms - radiotherapy; Anus Neoplasms - surgery; Biological and medical sciences; Dose Fractionation; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Lymphatic Metastasis; Male; Medical sciences; Melanoma - radiotherapy; Melanoma - secondary; Melanoma - surgery; Middle Aged; Neoplasm Invasiveness; Radiotherapy, Adjuvant; Rectal Neoplasms - pathology; Rectal Neoplasms - radiotherapy; Rectal Neoplasms - surgery; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Analysis; Treatment Outcome; Tumors; Human; Prognosis; Melanoma; Adjuvant treatment; Anorectal; Malignant tumor; Radiotherapy; Anal sphincter; Conservative surgery; Radiation injury; Digestive diseases; Intestinal disease; Complication; Combined treatment; Anorectal disease
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2002.03.002

To evaluate the outcome and toxicity of a sphincter-sparing treatment strategy in the management of patients with anal-rectal melanoma.
Between 1989 and 2000, 23 patients with invasive anal-rectal melanoma were managed with sphincter-sparing surgical resection and adjuvant radiation. Surgery consisted of primary local excision, as well as dissection for patients with documented regional nodal disease. Adjuvant radiation was delivered using a hypofractionated regimen of 30 Gy in five fractions over 2.5 weeks. Adjuvant systemic therapy was delivered to nine patients: cytotoxic chemotherapy in seven and immunotherapy in two.
After a median follow-up of 32 months, 15 patients had relapsed and 15 patients had died. The actuarial 5-year overall, disease-specific, disease-free, and distant metastasis-free survival rates were 31%, 36%, 37%, and 35%, respectively. The actuarial 5-year local and regional nodal control rates were 74% and 84%, respectively. No patient had locoregional failure as the sole site of failure and no patient required salvage abdominoperineal resection (APR). By univariate analysis, patients with nodal disease at presentation had a decreased actuarial 5-year disease-specific (0% v 45%, P =.004), disease-free (0% v 45%, P <.001), and distant metastasis-free survival (0% v 42%, P <.001). The actuarial complication-free survival rate was 71%. Two patients developed mild scrotal edema (grade 1), and four patients developed moderate proctitis requiring prolonged medical management (grade 2).
Sphincter-sparing local excision and adjuvant radiation is well tolerated and can effectively control local-regional disease while avoiding the functional morbidity of APR.