Respiratory Virus Infections in Pediatric Hematopoietic Stem Cell Transplantation

• Published in: Clinical infectious diseases Vol. 33; no. 7; pp. 962 - 968
• Main Authors: Luján-Zilbermann, Jorge, Benaim, Ely, Tong, Xin, Srivastava, Deo K., Patrick, Christian C., DeVincenzo, John P.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-10-2001; University of Chicago Press
• Subjects: Adenoviruses; Adenoviruses, Human - isolation & purification; Adolescent; Biological and medical sciences; Bone marrow; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation - adverse effects; Human respiratory syncytial virus; Human viral diseases; Humans; Infant; Infant, Newborn; Infections; Infectious diseases; Influenza A virus - isolation & purification; Influenza B virus - isolation & purification; Major Articles; Male; Medical sciences; Parainfluenza Virus 3, Human - isolation & purification; Paramyxoviridae infections; Pediatrics; Predisposing factors; Respiratory Syncytial Viruses - isolation & purification; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - virology; Retrospective Studies; Transplantation; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viral pneumonia; Virus Diseases - epidemiology; Virus Diseases - virology; Viruses; Human respiratory syncytial virus; Adenoviridae; Prognosis; Stem cell; Hematopoietic cell; Homograft; Orthomyxoviridae; Epidemiology; Paramyxoviridae; Incidence; Respiratory tract; Human adenovirus; Human parainfluenza virus 1; Graft; Human parainfluenza virus 4; Pneumovirus; Child; Human; Pneumovirinae; Respiratory disease; Influenzavirus; Infection; Virus; Paramyxovirinae; Symptomatology; Mononegavirales; Treatment; Viral disease; Rubulavirus; Risk factor; Mastadenovirus; Paramyxovirus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/322628

Respiratory virus infections (RVI) have become an increasingly appreciated problem in the hematopoietic stem cell transplant (HSCT) population. A retrospective analysis of 274 patients undergoing 281 HSCT at St. Jude Children's Research Hospital from January 1994 through December 1997 was performed. Medical and clinical laboratory records were reviewed beginning at the onset of conditioning through the year following each HSCT, and the analysis was done for the first RVI only. Thirty-two (11%) of 281 HSCT cases developed a RVI during the first year post-HSCT. The most frequent cause of RVI was human parainfluenza virus type 3. Univariate analysis was performed to determine the association between risk factors and the cumulative incidence of RVI. Respiratory viruses are frequent causes of infections in the first year post-HSCT in the pediatric population. Only allogeneic transplant and the degree of acute or chronic graft versus host disease were found to be statistically significant risk factors for RVI.