Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent

• Published in: Brain research Vol. 871; no. 1; pp. 146 - 150
• Main Authors: Prass, Konstantin, Wiegand, Frank, Schumann, Pascale, Ahrens, Melanie, Kapinya, Krisztian, Harms, Christoph, Liao, Weijing, Trendelenburg, George, Gertz, Karen, Moskowitz, Michael A, Knapp, Felix, Victorov, Ilya V, Megow, Dirk, Dirnagl, Ulrich
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 14-07-2000; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Biological and medical sciences; Brain Ischemia - physiopathology; Brain Ischemia - prevention & control; C57BL/6 mouse; Cerebral Infarction - pathology; Cerebral Infarction - prevention & control; Hyperbaric Oxygenation; Ischemic Preconditioning - methods; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurology; Oxygen free radical; Preconditioning; Species Specificity; Stroke; SV129 mouse; Vascular diseases and vascular malformations of the nervous system; C57BL/6 mouse; SV129 mouse; Stroke; Oxygen free radical; Disorders of the CNS; Preconditioning; Nervous system diseases; Rodentia; Hyperbaric oxygen; Tolerance; Cardiovascular disease; Free radical; Cerebral disorder; Vascular disease; Vertebrata; Experimental disease; Mammalia; Ischemia; Mouse; Animal; Central nervous system disease; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(00)02264-2

SV129 or C57BL/6 mice were exposed to hyperbaric oxygenation (HBO, 5 days, 1 h every day, 100% O
2 at 3 atm absolute). One day after the 5th HBO session focal cerebral ischemia was induced. In SV129 mice, HBO induced tolerance against permanent focal cerebral ischemia (
n=42, mean infarct volume reduction 27%,
P=0.001), but not against transient (30 or 60 min) focal cerebral ischemia. In the C57BL/6 strain of mice, HBO did not induce tolerance against focal cerebral ischemia, even when the duration of ischemia or the HBO protocol were modified. For the first time we demonstrate that HBO can induce tolerance to focal cerebral ischemia, but this effect is strain dependent.