The survival rate of laryngeal squamous cell carcinoma: impact of IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532 single nucleotide polymorphisms

• Published in: Discover. Oncology Vol. 14; no. 1; p. 8
• Main Authors: Pasvenskaite, Agne, Liutkeviciene, Rasa, Gedvilaite, Greta, Vilkeviciute, Alvita, Liutkevicius, Vykintas, Uloza, Virgilijus
• Format: Journal Article
• Language: English
• Published: New York Springer US 22-01-2023; Springer Nature B.V; Springer
• Subjects: Age; Alcohol; BLK rs13277113; Breastfeeding & lactation; Cancer; Cancer Research; Catheters; Cytokines; Endoscopy; General anesthesia; IL-6 rs1800795; IL1RAP rs4624606; IL1RL1 rs1041973; Infectious diseases; Internal Medicine; Laryngeal cancer; Laryngeal squamous cell carcinoma; Medical prognosis; Medicine; Medicine & Public Health; Molecular Medicine; Oncology; Otolaryngology; Population; Radiotherapy; Squamous cell carcinoma; Surgical Oncology; TIMP3 rs9621532; Lithuania; rs13277113; rs4624606; Laryngeal squamous cell carcinoma; rs1041973; rs9621532; rs1800795; BLK rs13277113; IL-6 rs1800795; IL1RAP rs4624606; TIMP3 rs9621532; IL1RL1 rs1041973
• ISSN: 2730-6011; 2730-6011
• DOI: 10.1007/s12672-023-00619-0

Purpose
Results of laryngeal squamous cell carcinoma (LSCC) treatment and the 5 year survival rate of these patients remain poor. To purify therapeutic targets, investigation of new specific and prognostic blood-based markers for LSCC development is essential.
Methods
In the present study, we evaluated five single nucleotide polymorphisms (SNPs):
IL1RAP
rs4624606,
IL1RL1
rs1041973,
IL-6
rs1800795,
BLK
rs13277113, and
TIMP3
rs9621532, and determined their associations with the patients’ 5 year survival rate. Also, we performed a detailed statistical analysis of different LSCC patients’ characteristics impact on their survival rate.
Results
Three hundred fifty-three LSCC patients and 538 control subjects were included in this study. The multivariable Cox regression analysis revealed a significant association between patients’ survival rate and distribution of
IL1RAP
rs4624606 variants: patients carrying AT genotype at
IL1RAP
rs4624606 had a lower risk of death (
p 
= 0.044). Also, it was revealed that tumor size (T) (
p
 = 0.000), tumor differentiation grade (G) (
p
 = 0.015), and
IL1RAP
rs4624606 genotype (
p
 = 0.044) were effective variables in multivariable Cox regression analysis prognosing survival of LSCC patients. The specific-LSCC 5 year survival rate was 77%.
Conclusions
In summary, our findings indicate that the genotypic distribution of
IL1RAP
rs4624606 influences the 5 year survival rate of LSCC patients. The results of the present study facilitate a more complete understanding of LSCC at the biological level, thus providing the base for the identification of new specific and prognostic blood-based markers for LSCC development.