Current status and future potential of transdermal drug delivery

• Published in: Nature reviews. Drug discovery Vol. 3; no. 2; pp. 115 - 124
• Main Authors: Mitragotri, Samir, Langer, Robert, Prausnitz, Mark R
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01-02-2004
• Subjects: Acoustic Stimulation; Administration, Cutaneous; Algorithms; Animals; Biological Transport, Active; Drug Delivery Systems; Electroporation; Excipients; Forecasts and trends; History; Humans; Iontophoresis; Nanotechnology; Needles; Skin Absorption - drug effects; Transdermal medication; Ultrasonics
• ISSN: 1474-1776; 1474-1784
• DOI: 10.1038/nrd1304

The past twenty five years have seen an explosion in the creation and discovery of new medicinal agents. Related innovations in drug delivery systems have not only enabled the successful implementation of many of these novel pharmaceuticals, but have also permitted the development of new medical treatments with existing drugs. The creation of transdermal delivery systems has been one of the most important of these innovations, offering a number of advantages over the oral route. In this article, we discuss the already significant impact this field has made on the administration of various pharmaceuticals; explore limitations of the current technology; and discuss methods under exploration for overcoming these limitations and the challenges ahead.