Lead blood concentrations and renal function evaluation: Study in an exposed Mexican population

• Published in: Environmental research Vol. 100; no. 2; pp. 227 - 231
• Main Authors: Hernández-Serrato, Maria I., Fortoul, Teresa Imelda, Rojas-Martínez, Rosalba, Mendoza-Alvarado, Laura R., Canales-Treviño, Lourdes, Bochichio-Riccardelli, Tommaso, Ávila-Costa, Maria Rosa, Olaiz-Fernández, Gustavo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01-02-2006; Elsevier
• Subjects: Adult; Biological and medical sciences; Blood Pb; Blood Proteins - metabolism; Chemical and industrial products toxicology. Toxic occupational diseases; Cooking and Eating Utensils; Creatinine - blood; Cross-Sectional Studies; Environmental Exposure - adverse effects; Female; Folk workers; Gender differences; Humans; Hyperuricemia; Kidney - drug effects; Kidney Diseases - blood; Kidney Diseases - chemically induced; Kidney Function Tests; Lead - blood; Lead Poisoning - blood; Lead Poisoning - physiopathology; Male; Medical sciences; Metabolic diseases; Metals and various inorganic compounds; Mexico; Other metabolic disorders; Purines and pyrimidines (gout, hyperuricemia...); Renal function test; Serum Albumin - metabolism; Surveys and Questionnaires; Toxicology; Urea - blood; Uric Acid - blood; Central America; Mexico; America; Mexico, Oaxaca; Hyperuricemia; Blood Pb; Gender differences; Folk workers; Renal function test; Human; Evaluation; Renal function; Enamel; Container content interaction; Sex; Metabolic diseases; Occupational exposure; Epidemiology; Blood; Heavy metal; Lead; Pottery; Occupational medicine; Public health; Food
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2005.03.004

The relation of blood Pb concentrations and renal dysfunction has been reported in association with interstitial fibrosis, tubular atrophy, and decreased glomerular filtration. In this report information about blood Pb concentrations and renal function tests in a population from Oaxaca, Mexico is analyzed. The main changes found were that males had higher blood Pb concentrations than females (
P
<
0.0012
); the leading variables associated with this were occupation (glazed pottery workers,
P
=
0.0001
) and the use of glazed pottery for preparing meals (
P
=
0.0000
). Variables that better explain uric acid variability were blood Pb concentrations, sex, weight, and height (
r
2
=
0.23
). Hyperuricemia was associated with blood Pb concentrations above 40
μg/dL (OR=1.74, 95% CI, 1.12–2.61). SCr was associated with sex, age, and blood Pb, with coefficient
r
2
=
0.12
. Our findings might be related to inadequate control of oven emissions, a situation that will require further analysis and the implementation of preventive measurements for the nonoccupational exposed population.