Role of the vestibular system in sudden shutdown of renal sympathetic nerve activity during microgravity in rats

• Published in: Neuroscience letters Vol. 286; no. 1; pp. 61 - 65
• Main Authors: Fujiki, Nobuhiro, Hagiike, Masanobu, Tanaka, Kunihiko, Tsuchiya, Yo, Miyahara, Taro, Morita, Hironobu
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 26-05-2000; Elsevier
• Subjects: Animals; Aortic flow velocity; Arterial pressure; Baroreflex - physiology; Biological and medical sciences; Blood Flow Velocity - physiology; Blood Pressure - physiology; Denervation; Ear, Inner - surgery; Fluid Shifts - physiology; Free-drop; Fundamental and applied biological sciences. Psychology; Kidney - innervation; Kidney - physiology; Labyrinthectomy; Male; Microgravity; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Nerve Degeneration - chemically induced; Rats; Rats, Sprague-Dawley; Reflex - physiology; renal sympathetic nerve; Renal sympathetic nerve activity; Space life sciences; Sympathetic Fibers, Postganglionic - physiology; Vertebrates: nervous system and sense organs; Vestibular Nerve - physiology; Vestibular Nuclei - physiology; Vestibule, Labyrinth - physiology; Vestibulosympathetic reflex; Weightlessness - adverse effects; Free-drop; Renal sympathetic nerve activity; Arterial pressure; Vestibulosympathetic reflex; Labyrinthectomy; Aortic flow velocity; Microgravity; Rat; Rodentia; Sympathetic nervous system; Inner ear; Vertebrata; Mammalia; Autonomic nervous system; Hemodynamics; Vestibular system; Renal nerve
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(00)01071-5

The purpose of this study was to examine the effect of microgravity (μG) on renal sympathetic nerve activity (RNA) in rats. Additionally, we estimated the participation of the vestibular system in the response of RNA to μG. Eight normal Sprague–Dawley (SD) rats and five chemically and bilaterally labyrinthectomied SD rats were used to measure RNA during free-drop examination (4.5-s duration of μG); arterial pressure (AP) and aortic flow velocity (AFV) were additionally monitored. Although AFV showed no particular change, AP tended to decrease during μG in the later phase. Prior to this AP fall-off, RNA was immediately and markedly attenuated by μG. This attenuation was transient and RNA returned to 1G level within the μμG condition. Interestingly, this phenomenon remained even in labyrinthectomied rats. In conclusion, cephalad shift of the body fluid by loading of μG may cause cardiopulmonary low-pressure receptor activation and consequent RNA attenuation, but the participation of the vestibulosympathetic reflex in this phenomenon is not obvious.