The Influence of Tumor Necrosis Factor–α and Interleukin-10 Gene Promoter Polymorphism on the Inflammatory Response in Experimental Human Endotoxemia

• Published in: Clinical infectious diseases Vol. 33; no. 9; pp. 1601 - 1603
• Main Authors: Fijen, J. W., Tulleken, J. E., Hepkema, B. G., van der Werf, T. S., Ligtenberg, J. J. M., Zijlstra, J. G.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University Chicago Press 01-11-2001; University of Chicago Press
• Subjects: Adult; Alleles; Bacterial diseases; Biological and medical sciences; Blood; Brief Reports; Cytokines; Endotoxemia; Endotoxemia - blood; Endotoxemia - genetics; Endotoxemia - immunology; Endotoxins; Experimental bacterial diseases and models; Health outcomes; Humans; Infectious diseases; Interleukin-10 - blood; Interleukin-10 - genetics; Male; Medical sciences; Polymerase chain reaction; Polymorphism, Genetic; Promoter Regions, Genetic; Sepsis; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - genetics; Tumor necrosis factors; Volunteerism; Human; Experimental disease; Gene; Pathogenesis; Transcription promoter; Interleukin 10; Inflammation; Endotoxemia; Tumor necrosis factor α
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/323197

In this study, we show that there is no correlation between tumor necrosis factor-α gene promoter polymorphism at position -308, interleukin-10 gene promoter polymorphism at position -1082, and the cytokine levels they produce in the human endotoxemia model.