Pemphigus foliaceus with prominent neutrophilic pustules

• Published in: British journal of dermatology (1951) Vol. 145; no. 1; pp. 132 - 136
• Main Authors: Matsuo, K., Komai, A., Ishii, K., Futei, Y., Amagai, M., Deguchi, H., Danno, K., Hashimoto, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-07-2001; Blackwell; Oxford University Press
• Subjects: Adult; Aged; Autoantigens - immunology; Biological and medical sciences; Bullous diseases of the skin; Cadherins - immunology; Dermatology; Desmoglein 1; Female; Humans; Immunoglobulin A - analysis; Immunoglobulin G - analysis; Male; Medical sciences; Neutrophil Infiltration; neutrophilic pustules; Pemphigus - immunology; Pemphigus - pathology; pemphigus foliaceus; Skin Diseases, Vesiculobullous - immunology; Skin Diseases, Vesiculobullous - pathology; Bullous dermatosis; Human; Immunopathology; Skin disease; Antibody; Pemphigus foliaceous; Autoantibody; IgG; Autoimmune disease; Pustule; Case study; Immunological investigation; Immunoblotting assay; Desmoglein 1; Skin; Immunofluorescence
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1046/j.1365-2133.2001.04297.x

We describe four patients with generalized scaly and pustular skin lesions showing extensive neutrophilic infiltration in the subcorneal region of the epidermis. Immunofluorescence, immunoblot and enzyme‐linked immunosorbent assay analyses detected IgG antibodies reacting exclusively with desmoglein 1, the pemphigus foliaceus antigen. This study indicates that pemphigus foliaceus may show prominent neutrophilic pustular skin lesions.