Ligand-Enabled Arylation of γ-C−H Bonds

PdII‐catalyzed arylation of γ‐C(sp3)−H bonds of aliphatic acid‐derived amides was developed by using quinoline‐based ligands. Various γ‐aryl‐α‐amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated. P...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 55; no. 13; pp. 4317 - 4321
Main Authors:	Li, Suhua, Zhu, Ru-Yi, Xiao, Kai-Jiong, Yu, Jin-Quan
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 18-03-2016 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Aliphatic compounds Amides Amino acids Amino Acids - chemistry Aromatic compounds arylation Carbon - chemistry carboxylic acids Hydrogen - chemistry Ligands palladium Quinoline quinoline ligand γ-C-H activation palladium quinoline ligand γ-C-H activation carboxylic acids arylation
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Summary:	PdII‐catalyzed arylation of γ‐C(sp3)−H bonds of aliphatic acid‐derived amides was developed by using quinoline‐based ligands. Various γ‐aryl‐α‐amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated. PdII‐catalyzed arylation of γ‐C(sp3)−H bonds of aliphatic acid‐derived amides was developed by using quinoline‐based ligands. Various γ‐aryl‐α‐amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.
Bibliography:	istex:B9D7D34336C4B5C5A771468D31C8BC40CE4B2BCE ark:/67375/WNG-7MLNGTJ2-C ArticleID:ANIE201512020 NIH - No. 2R01GM084019 The Scripps Research Institute ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201512020