Type 2 diabetes mellitus disease risk genes identified by genome wide copy number variation scan in normal populations

Highlights • CNV analysis was carried out on a total of 1715 individuals from 12 populations. • 34.4% of the total population to be under CNV burden for T2DM. • Eighty-three disease causal and associated genes were found under CNV influence. • Overlap studies with case cohorts revealed CNV influence...

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Bibliographic Details
Published in:	Diabetes research and clinical practice Vol. 113; pp. 160 - 170
Main Authors:	Prabhanjan, Manasa, Suresh, Raviraj V, Murthy, Megha N, Ramachandra, Nallur B
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-03-2016
Subjects:	Adolescent Adult Aged Computational Biology Copy number variations Diabetes Mellitus, Type 2 - genetics DNA Copy Number Variations Endocrinology & Metabolism Enrichment Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Middle Aged Molecular interaction and network Phenotype Type 2 diabetes mellitus Young Adult Enrichment Type 2 diabetes mellitus Copy number variations Molecular interaction and network
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Summary:	Highlights • CNV analysis was carried out on a total of 1715 individuals from 12 populations. • 34.4% of the total population to be under CNV burden for T2DM. • Eighty-three disease causal and associated genes were found under CNV influence. • Overlap studies with case cohorts revealed CNV influence on significant disease risk genes such as EGFR, E2F1, PPP1R3A, HLA and TSPAN8.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.12.015