No genetic association between SLC7A10 and Japanese patients with schizophrenia

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 35; no. 8; pp. 1965 - 1968
• Main Authors: Takebayashi, Yuto, Ohnuma, Tohru, Hanzawa, Ryo, Shibata, Nobuto, Maeshima, Hitoshi, Baba, Hajime, Hatano, Tokiko, Hotta, Yuri, Kitazawa, Maiko, Higa, Motoyuki, Arai, Heii
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01-12-2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Amino Acid Transport System y+ - genetics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Case-Control Studies; Excitatory amino acid transporters (EAATs); Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Glutamate; Haplotypes; Humans; Japan; Linkage Disequilibrium; Male; Medical sciences; Middle Aged; Neuropharmacology; Pharmacology. Drug treatments; Polymorphism; Polymorphism, Single Nucleotide; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - genetics; Solute carrier family 7 member 10 (SLC7A10); Asia; Japan; GLYT; DSM-IV; Schizophrenia; Solute carrier family 7 member 10 (SLC7A10); Excitatory amino acid transporters (EAATs); SLC7A10; Glutamate; CP; EAAT; BPRS; CGI-I; SNP; TRS; HWE; LD; NMDA; CGI-S; ASCT; Polymorphism; Human; Japanese; Psychosis; Neurotransmitter; Excitatory aminoacid; Family environment; Genetics; Carrier protein
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2011.08.012

Disrupted glutamatergic neurotransmission may be a pathophysiological feature in the brains from patients with schizophrenia, and glutamatergic amino acids including d-serine have been found to be involved in pathophysiology. Endogenous and exogenous d-serine have shown potential as biological markers for the pathophysiology of schizophrenia and especially as a therapeutic strategy in treatment-resistant schizophrenia (TRS). This is the first study investigating whether SLC7A10, a d-serine transporter gene, is associated with schizophrenia in Japanese patients.
We investigated the association between schizophrenia in Japanese patients with SLC7A10 using six tag single nucleotide polymorphisms (SNPs). Results failed to show any association between Japanese schizophrenia and each individual SNP or with two-, three-, or four-window haplotype analyses. We also investigated whether SLC7A10 contributes to TRS in Japanese participants. Results showed no association.
In conclusion, SLC7A10 had no apparent degree of association with schizophrenia as a candidate susceptibility gene in the disease per se.
► SCL7A10, a D-serine transporter might be a susceptibility gene for schizophrenia. ► We examined whether SLC7A10 were related to Japanese schizophrenia. ► SLC7A10 had no association with Japanese patients with schizophrenia.