Pioneer factors in viral infection

Pioneer factors in viral infection

Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing zygotic genome activation or cell fate decisi...

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Bibliographic Details
Published in:Frontiers in immunology Vol. 14; p. 1286617
Main Authors: Neugebauer, Eva, Bastidas-Quintero, Aura M, Weidl, Daniel, Full, Florian
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 09-10-2023
Subjects:
development
DNA-virus
herpesvirus
Humans
Immunology
pioneer factor
Signal Transduction
transcription factor
Transcription Factors - metabolism
virus
Virus Diseases
Virus Replication - physiology
transcription factor
development
herpesvirus
pioneer factor
DUX4
virus
DNA-virus
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Summary:Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing zygotic genome activation or cell fate decision. Some pioneer factors are actively induced or downregulated by viral infection. With this, viruses are capable to modulate different signaling pathways resulting for example in MHC-receptor up/downregulation which contributes to viral immune evasion. In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replication and persistence in the host, as well as for the development of viral cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
Reviewed by: Igor Jurak, University of Rijeka, Croatia; Michael M. Nevels, University of St Andrews, United Kingdom
Edited by: Vu Thuy Khanh Le-Trilling, Essen University Hospital, Germany
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1286617