Reduced Tolerance to Certain Pharmacological Effects of Ethanol After Chronic Administration in Perinatally Undernourished Rats

• Published in: Pharmacology, biochemistry and behavior Vol. 57; no. 4; pp. 659 - 663
• Main Authors: Cordoba, Nancy E, Borghese, Cecilia M, Arolfo, Maria Pia, Orsingher, Otto A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-08-1997; Elsevier Science
• Subjects: Alcoholism and acute alcohol poisoning; Animals; Anti-Anxiety Agents - pharmacology; Anticonvulsant; Biological and medical sciences; Body Temperature - drug effects; Chronic ethanol; Diet, Protein-Restricted; Drug Tolerance; Ethanol - administration & dosage; Ethanol - pharmacology; Female; Hypoalgesia; Hypothermia; Medical sciences; Pain Measurement - drug effects; Perinatal undernutrition; Pregnancy; Prenatal Exposure Delayed Effects; Protein-Energy Malnutrition - physiopathology; Rat; Rats; Rats, Wistar; Seizures - physiopathology; Tolerance; Toxicology; Rat; Perinatal undernutrition; Tolerance; Anticonvulsant; Chronic ethanol; Hypoalgesia; Hypothermia; Pregnancy; Progeny; Vertebrata; Intraperitoneal administration; Mammalia; Ethanol; Animal; Rodentia; Malnutrition
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/S0091-3057(96)00392-9

We have previously reported that recovered adult rats undernourished at perinatal age failed to develop tolerance to the anticonflict effect of ethanol after chronic ethanol administration (1 g/kg/day during 30 days)
[4]. To further study the extent of this finding, we examined the effect of a similar chronic ethanol treatment on the hypothermic and anticonvulsant effects of ethanol in perinatally deprived rats. Hypoalgesic activity was assessed in ethanol treated rats during 15 days. After chronic ethanol treatment, a similar development of tolerance to the hypothermic effect of ethanol was observed in control and deprived rats. However, tolerance to the anticonvulsant and hypoalgesic effect of ethanol was significantly reduced in deprived as compared with control animals. Thus, early undernutrition differentially affects the development of tolerance elicited by chronic ethanol administration.