Stereoselective synthesis of the antifungal GM222712

An efficient and convergent synthesis of the antifungal agent GM222712 is described. The approach involves the preparation of the modified sugar moiety followed by its stereoselective anomeric O-alkylation with sordaricin triflate 19.

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 41; no. 22; pp. 4379 - 4382
Main Authors:	Bueno, José M, Coterón, José M, Chiara, Jose Luis, Fernández-Mayoralas, Alfonso, Fiandor, José M, Valle, Nuria
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 08-06-2000
Subjects:	alkylation antifungals carbohydrates radical and radical reactions carbohydrates alkylation antifungals radical and radical reactions
Online Access:	Get full text
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Description
Summary:	An efficient and convergent synthesis of the antifungal agent GM222712 is described. The approach involves the preparation of the modified sugar moiety followed by its stereoselective anomeric O-alkylation with sordaricin triflate 19.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/S0040-4039(00)00655-9