Correlation of body muscle/fat ratio with insulin sensitivity using hyperinsulinemic-euglycemic clamp in treatment-naïve type 2 diabetes mellitus

• Published in: Diabetes research and clinical practice Vol. 120; pp. 65 - 72
• Main Authors: Kurinami, Noboru, Sugiyama, Seigo, Yoshida, Akira, Hieshima, Kunio, Miyamoto, Fumio, Kajiwara, Keizo, Jinnouchi, Tomio, Jinnouchi, Hideaki
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-10-2016
• Subjects: Adipose Tissue - drug effects; Adipose Tissue - metabolism; Body Composition; Body fat; Body muscle; Diabetes mellitus; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Endocrinology & Metabolism; Female; Glucose Clamp Technique - methods; Glucose Intolerance - etiology; Humans; Insulin resistance; Insulin Resistance - physiology; Male; Middle Aged; Muscles - drug effects; Muscles - metabolism; Obesity; Obesity - complications; Obesity - physiopathology; Obesity; Insulin resistance; Body muscle; Body fat; Diabetes mellitus
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2016.07.018

Highlights • Body composition assessed by InBody770 is significantly related to insulin resistance, particularly Muscle / Fat ratio. • The Muscle / Fat ratio is clinically useful to predict the presence of insulin resistance in patients with untreated Diabetes. • Insulin resistance reference indicator (M/I value) assessed by hyperinsulinemic-euglycemic clamp examination can be estimated with the regression equation; M/I value=3.0990x(muscle/fat ratio)+1.1285. • Cutoff value for the presence of insulin resistance is Muscle / Fat ratio=2.40.