The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases

• Published in: Leukemia research Vol. 37; no. 4; pp. 396 - 400
• Main Authors: Kiran, Tugce, Demirkesen, Cuyan, Eker, Candan, Kumusoglu, Hakki, Tuzuner, Nukhet
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-04-2013
• Subjects: Adolescent; Adult; Aged; ALCL; CD30; Child; Child, Preschool; Cutaneous lymphomas; Female; Hematology, Oncology and Palliative Medicine; Humans; Infant; Interferon Regulatory Factors - metabolism; IRF4 translocation; Ki-1 Antigen - metabolism; Lymphoproliferative Disorders - metabolism; Male; Middle Aged; MUM1; Protein Transport; Skin Neoplasms - metabolism; T-Lymphocytes - metabolism; Young Adult; MUM1; CD30; IRF4 translocation; Cutaneous lymphomas; ALCL
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2012.12.001

Abstract Current laboratory technics, clinicopathologic findings cannot always reliably distinguish primary cutaneous CD30(+) lymphoproliferative disorders (LPD), such as lymphomatoid papulosis (LyP), primary cutaneous CD30(+) anaplastic large cell lymphoma (PCALCL), transformed mycosis fungoides (T-MF) and systemic ALK(−) anaplastic large cell lymphoma (ALCL) with skin involvement. We investigated the presence of IRF4 translocation with break apart DNA-FISH method of these entities according to the recent studies of Feldman et al. In our study group with 53 cases, the detection of IRF4 translocation had a specificity and positive predictive value for PCALCL of 100%. In contrast MUM1/IRF4 protein expression was distributed widely without any predictive value.