The effects of Hyperventilation on Axonal Excitability Parameters in Patients with Diabetes Mellitus and Polyneuropathy

Highlights • This study’s findings support the decrease in sensitivity to alcalosis of persistent Na+ channels in diabetic polyneuropathy. • Insensitivity to hiperventilation of the patients with diabetic polyneuropathy seems to be related to nodal Na channel pathology as well as internodal K channe...

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Bibliographic Details
Published in:	Diabetes research and clinical practice Vol. 118; pp. 112 - 120
Main Authors:	Akça, Gökçen, Yerdelen, Deniz, Balcı, Mustafa Kemal, Uysal, Hilmi
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-08-2016
Subjects:	Action Potentials Axonal excitability Axons - physiology Case-Control Studies Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetic Neuropathies - physiopathology Endocrinology & Metabolism Female Humans Hyperventilation Male Median Nerve - physiopathology Middle Aged Polyneuropathy Axonal excitability Polyneuropathy Hyperventilation Diabetes mellitus
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Summary:	Highlights • This study’s findings support the decrease in sensitivity to alcalosis of persistent Na+ channels in diabetic polyneuropathy. • Insensitivity to hiperventilation of the patients with diabetic polyneuropathy seems to be related to nodal Na channel pathology as well as internodal K channels’ becoming sensitive to pH changes because of retraction of the myelin sheet from paranodal region. • TEd (peak) part of threshold electrotonus have a tendency to increase. This tendency might be related with paranodal and internodal influences due to polyneuropathic process.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2016.04.058