Mucosa-associated lymphoid tissue lymphoma of the trachea: case report

• Published in: São Paulo medical journal Vol. 130; no. 2; pp. 126 - 129
• Main Authors: Magliari, Maria Elisa Ruffolo, Aquino, Renata Telles Rudge de, Gonçalves, Anna Luiza Lobão, Marioni, Fábio, Bernardi, Fabíola del Carlo, Brasil, Sérgio, Almeida, Joaquim Antonio da Fonseca, Andrade, Benedito Juarez, Chiattone, Carlos Sérgio, Lima, Carlos Alberto da Conceição
• Format: Journal Article
• Language: English
• Published: Brazil Associação Paulista de Medicina - APM 01-01-2012; Associação Paulista de Medicina
• Subjects: Aged; Antibodies, Monoclonal, Murine-Derived - administration & dosage; Antineoplastic Agents - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; B-Cell; Case Report; Cyclophosphamide - administration & dosage; Diagnosis, Differential; Female; Humans; Lymphoma; Lymphoma, B-Cell, Marginal Zone - drug therapy; Lymphoma, B-Cell, Marginal Zone - pathology; marginal zone; MEDICINE, GENERAL & INTERNAL; Neoplasms; non-Hodgkin; Prednisone - administration & dosage; Remission Induction; Rituximab; Tracheal neoplasms; Tracheal Neoplasms - drug therapy; Tracheal Neoplasms - pathology; Vincristine - administration & dosage; Neoplasias; Neoplasias da traquéia; Tracheal neoplasms; non-Hodgkin; B-Cell; Linfoma de zona marginal tipo células B; marginal zone; Linfoma; Linfoma não Hodgkin; Lymphoma; Neoplasms
• ISSN: 1516-3180; 1806-9460; 1806-9460; 1516-3180
• DOI: 10.1590/S1516-31802012000200010

Mucosa-associated lymphoid tissue (MALT) lymphomas are most commonly found in the stomach, lungs, orbital soft tissue, salivary glands and thyroid. Involvement of the trachea is extremely rare.
This report describes a rare case of MALT lymphoma of the trachea in a 71-year-old woman who presented with a one-year history of coughing, dyspnea, hoarseness and weight loss. There was an infiltrative lesion in the mid-trachea. The anatomopathological diagnosis was only made from the fifth endoscopic biopsy attempt. Immunochemotherapy consisting of rituximab, cyclophosphamide, vincristine and prednisone (R-COP) induced complete remission of the symptoms and endoscopic lesion.
MALT lymphoma of the trachea is extremely rare and indolent disease. It has to be considered in the differential diagnosis of airway lesions. It is crucial to obtain an anatomopathological diagnosis from a specialized pathologist. Immunochemotherapy with R-COP induced complete remission of the disease.