Gastric Pepsin and Acid Secretion during Total Parenteral Nutrition and Constant-Rate Enteral Nutrition in Infancy

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 12; no. 5; pp. 505 - 508
• Main Authors: De Angelis, G.L., Poitevin, C., Cezard, J.P., Vatier, J., Foucaud, P., Navarro, J.
• Format: Journal Article
• Language: English
• Published: Thousand Oaks, CA Sage Publications 01-09-1988; SAGE Publications; ASPEN
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Enteral Nutrition - methods; Gastric Acid - secretion; Humans; Infant; Intensive care medicine; Medical sciences; Parenteral Nutrition, Total; Pepsin A - secretion; Human; Infant; Acidity; Pepsin; Gastric juice; Resuscitation; Enteral administration; Parenteral administration; Feeding
• ISSN: 0148-6071; 1941-2444
• DOI: 10.1177/0148607188012005505

Total Parenteral Nutrition (TPN) and constant rate enteral nutrition (CREN) are widely used: their effects on gastric function, especially pepsin secretion, are unknown. Basal and pentagastrin-stimulated pepsin (BPO, MPO) and acid (BAO, MAO) secretions were measured in three groups of infants: controls (14 infants fed normally), TPN groups (seven infants on TPN), CREN groups (14 infants on CREN). The MAO and MPO of the TPN group were significantly lower than controls (p < 0.02), and the ratio of pentagastrin-stimulated PO/AO did not change, suggesting a large decrease of acid gastric function in the TPN group. BPO was not different from controls and BAO was significantly higher because of amino acids perfusion. The data for CREN group were not different from those of the control group, despite the fact that 11 infants were on TPN before CREN. These results demonstrate that TPN causes decreases in both acid and pepsin secretions in human infants. When TPN children are placed on CREN, these secretions return to normal. (Journal of Parenteral and Enteral Nutrition
12:505-508, 1988)