Serum adiponectin levels in cholesterol and pigment cholelithiasis

Background: Altered adiponectin levels are associated with metabolic abnormalities. The aim of this study was to explore the role of adiponectin in cholelithiasis. Methods: A radioimmunoassay was used to determine serum adiponectin levels in 58 patients with cholesterol gallstones and 47 with pigmen...

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Published in:British journal of surgery Vol. 93; no. 8; pp. 981 - 986
Main Authors: Wang, S.-N., Yeh, Y.-T., Yu, M.-L., Wang, C.-L., Lee, K.-T.
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-08-2006
Wiley
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Summary:Background: Altered adiponectin levels are associated with metabolic abnormalities. The aim of this study was to explore the role of adiponectin in cholelithiasis. Methods: A radioimmunoassay was used to determine serum adiponectin levels in 58 patients with cholesterol gallstones and 47 with pigment gallstones, and 101 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: The mean(s.d.) adiponectin level was decreased in patients with cholesterol gallstones (7·6(4·1) µg/ml; P < 0·001) but raised in patients with pigment gallstones (17·9(9·0) µg/ml; P < 0·001) in comparison with healthy controls (11·7(6·5) µg/ml). Decreased adiponectin levels (odds ratio (OR) 0·85 (95 per cent confidence interval (c.i.) 0·76 to 0·96); P = 0·008) and female sex (OR 6·06 (95 per cent c.i. 2·10 to 17·46); P = 0·001) were associated with cholesterol gallstone formation. Increased adiponectin levels (OR 1·11 (95 per cent c.i. 1·01 to 1·22); P = 0·025) and increased age (OR 1·06 (95 per cent c.i. 1·01 to 1·12); P = 0·029) were associated with pigment gallstone formation. Raised serum aspartate aminotransferase concentration was a risk factor for both cholesterol (OR 1·16 (95 per cent c.i. 1·03 to 1·30); P = 0·013) and pigment (OR 1·23 (95 per cent c.i. 1·10 to 1·38); P < 0·001) gallstones. Conclusion: Gallstone formation is associated with altered serum adiponectin levels. Serum adiponectin might serve as a novel marker for cholesterol and pigment cholelithiasis. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. A new marker for gallstones
Bibliography:istex:16CF4DCA10B8E82E2A93A19B9D355E2CF632A6CA
ArticleID:BJS5395
ark:/67375/WNG-HN0TFX3S-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5395