Stanniocalcin 1 Enhances Carbon Flux from Glucose to Lipids in White Retroperitoneal Adipose Tissue in the Fed Rat

• Published in: Lipids Vol. 51; no. 11; pp. 1303 - 1307
• Main Authors: Cozer, Aline G., Trapp, Márcia, Vieira Marques, Claudia, Martins, Tiago L., Model, Jorge Felipe A., Schein, Vanessa, Kucharski, Luiz Carlos, Da Silva, Roselis S. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2016; Springer Nature B.V
• Subjects: Adenosine diphosphate; Adenosine Triphosphate - metabolism; Adipose tissue; Adipose Tissue, White - metabolism; Animals; Biomedical and Life Sciences; Body fat; Carbon Dioxide - metabolism; Endocrinology; Fatty Acids - metabolism; Glucose; Glucose - metabolism; Glycoproteins - metabolism; Humans; Incubation; Life Sciences; Lipid Metabolism; Lipidology; Lipids; Lipogenesis; Male; Medical Biochemistry; Medicinal Chemistry; Microbial Genetics and Genomics; Neurochemistry; Nutrition; Oxidation-Reduction; Rapid Communication; Rats; Rats, Wistar; Endocrinology; Lipid metabolism
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/s11745-016-4202-5

The present work assesses
in vitro
the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of
14
C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on
de novo
fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in
14
CO
2
production from
14
C-glucose. The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC-1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC-1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.