Effect of work conditions and work environments on the formation of 8-OH-dG in nurses and non-nurse female workers

• Published in: Journal of UOEH Vol. 30; no. 3; p. 293
• Main Authors: Ishihara, Itsuko, Nakano, Masahiro, Ikushima, Miharu, Hara, Yoshiko, Yoshimine, Toshiko, Haraga, Miki, Nakatani, Junko, Kawamoto, Rieko, Kasai, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan 01-09-2008
• Subjects: Adolescent; Adult; Aged; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Depression - urine; Female; Humans; Male; Middle Aged; Nurses; Stress, Psychological - urine
• ISSN: 0387-821X
• DOI: 10.7888/juoeh.30.293

The purpose of our study was to examine the effects of job stress factors on oxidative DNA injuries among female workers. The levels of urinary 8-hydroxydeoxyguanosine (8-OH-dG) were measured along with a survey on work conditions and environments. The result showed that female workers in shift work excreted increased levels of 8-OH-dG in comparison with the result of those who were engaged in part time work (P < 0.01). Moreover, the nurses who marked higher depressive scores excreted significantly increased levels of urinary 8-OH-dG than the nurses who scored lower depressive states. The result revealed a positive correlation between 8-OH-dG levels of nurses in the 35-45 age group and the individual scores of their depressive states (r = 0.32, P < 0.05). Together, it was suggested that a heavy burden of work in addition to daily domestic roles increases urinary excretion levels of 8-OH-dG.