In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin-Resistant Staphylococcus aureus

• Published in: Phytotherapy research Vol. 27; no. 8; pp. 1260 - 1264
• Main Authors: Eom, Sung-Hwan, Kim, Do-Hyung, Lee, Sang-Hoon, Yoon, Na-Young, Kim, Ji Hoe, Kim, Tae Hoon, Chung, Yong-Hyun, Kim, Seon-Bong, Kim, Young-Man, Kim, Hyun-Woo, Lee, Myung-Suk, Kim, Young-Mog
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-08-2013; Wiley Subscription Services, Inc
• Subjects: Ampicillin; Ampicillin - pharmacology; Animals; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; antibacterial activity; Benzofurans - isolation & purification; Benzofurans - pharmacology; Dioxins - isolation & purification; Dioxins - pharmacology; Drug Synergism; Eisenia bicyclis; methicillin-resistant Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Oxacillin - pharmacology; Penicillins - pharmacology; Phaeophyceae - chemistry; phlorotannins; Tannins - isolation & purification; Tannins - pharmacology; antibacterial activity; methicillin-resistant Staphylococcus aureus; phlorotannins; Eisenia bicyclis
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.4851

Six phlorotannins, isolated from Eisenia bicyclis, were evaluated for antibacterial activity against methicillin‐resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol‐A (PFF) exhibited the highest anti‐MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β‐lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti‐MRSA activity of phlorotannins from E. bicyclis. The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA. Copyright © 2012 John Wiley & Sons, Ltd.