A primate temporal cortex–zona incerta pathway for novelty seeking

• Published in: Nature neuroscience Vol. 25; no. 1; pp. 50 - 60
• Main Authors: Ogasawara, Takaya, Sogukpinar, Fatih, Zhang, Kaining, Feng, Yang-Yang, Pai, Julia, Jezzini, Ahmad, Monosov, Ilya E.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-01-2022; Nature Publishing Group
• Subjects: 631/378/1662; 631/378/2649/1662; 631/477; 64; Animal Genetics and Genomics; Animals; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Cortex (temporal); Dopamine; Exploratory Behavior; Eye movements; Habenula; Inactivation; Monkeys; Neurobiology; Neurons; Neurosciences; Primates; Reinforcement; Sensory stimulation; Substantia nigra; Temporal Lobe; Zona Incerta
• ISSN: 1097-6256; 1546-1726
• DOI: 10.1038/s41593-021-00950-1

Primates interact with the world by exploring visual objects; they seek opportunities to view novel objects even when these have no extrinsic reward value. How the brain controls this novelty seeking is unknown. Here we show that novelty seeking in monkeys is regulated by the zona incerta (ZI). As monkeys made eye movements to familiar objects to trigger an opportunity to view novel objects, many ZI neurons were preferentially activated by predictions of novel objects before the gaze shift. Low-intensity ZI stimulation facilitated gaze shifts, whereas ZI inactivation reduced novelty seeking. ZI-dependent novelty seeking was not regulated by neurons in the lateral habenula or by many dopamine neurons in the substantia nigra, traditionally associated with reward seeking. But the anterior ventral medial temporal cortex, an area important for object vision and memory, was a prominent source of novelty predictions. These data uncover a functional pathway in the primate brain that regulates novelty seeking.
Primates seek opportunities to view novel objects even when these objects have no extrinsic reward value. Ogasawara et al. show that this novelty seeking is regulated by a temporal cortex→zona incerta pathway, rather than by dopamine neurons.