8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?

• Published in: International journal of molecular sciences Vol. 25; no. 2; p. 1342
• Main Authors: Kruchinin, Alexander A, Kamzeeva, Polina N, Zharkov, Dmitry O, Aralov, Andrey V, Makarova, Alena V
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-01-2024
• Subjects: 7,8-dihydro-8-oxoadenine; Adenine - chemistry; Animals; Aqueous solutions; base excision repair; DNA; DNA Damage; DNA glycosylases; DNA polymerase; DNA polymerases; DNA Repair; DNA-Directed DNA Polymerase - metabolism; Enzymes; Ethylenediaminetetraacetic acid; Fourier transforms; Genetic testing; Geometry; Mammals - metabolism; Metabolism; Mutagenesis; Mutagens; Mutation; Oxidation; Oxidative Stress; Radiation; translesion DNA synthesis; Russia; DNA polymerases; base excision repair; DNA glycosylases; 7,8-dihydro-8-oxoadenine; translesion DNA synthesis; mutagenesis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25021342

Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes.