Functional connectivity alteration of the deprived auditory regions with cognitive networks in deaf and inattentive adolescents

• Published in: Brain imaging and behavior Vol. 16; no. 2; pp. 939 - 954
• Main Authors: Li, Jianhong, Men, Weiwei, Gao, Jia-Hong, Wang, Yang, Qu, Xiaoxia, Zhu, David Chao Dong, Xian, Junfang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-04-2022; Springer Nature B.V
• Subjects: Adolescent; Adolescents; Attention; Auditory Cortex - diagnostic imaging; Biomedical and Life Sciences; Biomedicine; Brain; Brain Mapping; Cognition; Cognitive ability; Cortex (auditory); Cortex (temporal); Deafness; Deafness - diagnostic imaging; Functional magnetic resonance imaging; Hearing aids; Hearing Loss; Humans; Language; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Networks; Neural networks; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Psychiatry; Sensorimotor system; Sign language; Teenagers; Functional connectivity; Attentional deficit; Deafness; Adolescents; Resting-state functional magnetic resonance imaging
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-022-00632-x

Adolescents with early profound deafness may present with distractibility and inattentiveness. The brain mechanisms underlying these attention impairments remain unclear. We performed resting-state functional magnetic resonance imaging to investigate the functional connectivity of the superior temporal and transverse temporal gyri in 25 inattentive adolescents with bilateral prelingual profound deafness, and compared the results with those of 27 age-matched normal controls. Pearson and Spearman’s rho correlation analyses were used to investigate the correlations of altered functional connectivity with the clinical parameters, including the duration of hearing loss sign language, and hearing aid usage. Compared with normal controls, prelingual profound deafness demonstrated mainly decreased resting-state functional connectivity between the deprived auditory regions and several other brain functional networks, including the attention control, language comprehension, default-mode, and sensorimotor networks. Moreover, we also found enhanced resting-state functional connectivity between the deprived auditory cortex and salience network. These results indicate a negative impact of early hearing loss on the attentional and other high cognitive networks, and the use of sign language and hearing aids normalized the participants’ connectivity between the primary auditory cortex and attention networks, which is crucial for the early intervention and clinical care of deaf adolescents.