Croblongifolin, a new anticancer clerodane from Croton oblongifolius

A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity agains...

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Bibliographic Details
Published in:	Planta medica Vol. 68; no. 3; p. 274
Main Authors:	Roengsumran, Sophon, Musikul, Kusalin, Petsom, Amorn, Vilaivan, Tirayut, Sangvanich, Polkit, Pornpakakul, Surachai, Puthong, Songchan, Chaichantipyuth, Chaiyo, Jaiboon, Nongnuj, Chaichit, Narongsak
Format:	Journal Article
Language:	English
Published:	Germany 01-03-2002
Subjects:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Croton Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenes, Clerodane Doxorubicin - pharmacology Furans - chemistry Furans - isolation & purification Furans - pharmacology Humans Magnetic Resonance Spectroscopy Molecular Structure Plant Bark - chemistry Plant Extracts - pharmacology Tumor Cells, Cultured - drug effects X-Ray Diffraction
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Summary:	A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.
ISSN:	0032-0943
DOI:	10.1055/s-2002-23138