A single-site pilot feasibility randomized trial of a supportive care mobile application intervention for patients with advanced cancer and caregivers

• Published in: Supportive care in cancer Vol. 30; no. 10; pp. 7853 - 7861
• Main Authors: Merz, Alexandra, Mohamed, Amro, Corbett, Cheyenne, Herring, Kris, Hildenbrand, Jordan, Locke, Susan C., Patierno, Steven, Troy, Jesse, Wolf, Steven, Zafar, S. Yousuf, Chilcott, Jack, Higgins, Adam, Manassei, Hugo, McCoy, Colette, Buckingham, Trudy L., LeBlanc, Thomas W.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-10-2022; Springer; Springer Nature B.V
• Subjects: Cancer; Cancer patients; Care and treatment; Caregivers; Intervention; Medical care; Medicine; Medicine & Public Health; Nursing; Nursing Research; Oncology; Original Article; Pain Medicine; Palliative care; Patients; Quality management; Quality of life; Rehabilitation Medicine; Surveys; Usability; Wireless telephone software; mHealth; Supportive care; Patient-reported outcomes; Cancer
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-022-07224-x

Purpose
Mobile health interventions can improve patient care. We developed the Digital Supportive Care Awareness and Navigation (D-SCAN) application (app) to facilitate symptom monitoring and use/awareness of cancer supportive care resources. This study tested feasibility, usability/satisfaction, and preliminary efficacy of D-SCAN.
Methods
We randomized 50 patients with advanced cancer to receive the D-SCAN intervention or usual care; 10 caregivers also received D-SCAN. The primary feasibility outcome was determined by weekly symptom survey completion and end of study procedures. We assessed secondary outcomes including usability/satisfaction, awareness/use of supportive care resources, patient activation, and quality of life via various questionnaires including the Net Promoter Score (NPS), Patient Activation Measure (PAM-13), Functional Assessment of Cancer Therapy-General (FACT-G), and Caregiver Oncology Quality of Life (CarGOQOL) questionnaire.
Results
Seventy-six percent of intervention patients met feasibility criteria, exceeding our pre-determined threshold of 75%. Usability/satisfaction by NPS was high, at 14.3% and 12.5% for patients and caregivers, respectively. Intervention patient and caregiver resource awareness increased by a mean of 3.7 (
p
 = 0.27) and 4.1 items, respectively. Supportive care resource utilization increased by a mean of 0.8 items for intervention patients (
p
 = 0.70) and 0.6 for caregivers. PAM-13 increased by a mean of 1.6 for intervention patients (
p
 = 0.65). FACT-G increased by a mean of 1.1 for intervention patients (
p
 = 0.91), and CarGOQoL increased by a mean of 2.2 (
p
 = 0.41).
Conclusion
D-SCAN is a feasible, usable, and satisfactory intervention for augmenting patient and caregiver supportive care. Further testing is necessary to formally assess D-SCAN’s efficacy and impact on patients and caregivers.
Clinical trial registration number. NCT03628794. Registered on August 14th, 2018.