Variation in the dielectric properties of freshly excised colorectal cancerous tissues at different tumor stages

• Published in: Bioelectromagnetics Vol. 38; no. 7; pp. 522 - 532
• Main Authors: Li, Zhou, Wang, Weiwei, Cai, Zhai, Han, Shuai, Lin, Shiming, He, Linyun, Chen, Miaoliang, Pan, Dongyue, Deng, Guanhua, Duan, Song, Xin, Sherman Xuegang
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-10-2017
• Subjects: Adult; Aged; Aged, 80 and over; Colorectal cancer; Colorectal Neoplasms - pathology; Conductivity; Dielectric properties; Electric Impedance; Electrical properties; Electrical resistivity; Female; Humans; Intestinal Mucosa - cytology; Intestinal Mucosa - pathology; Magnetic properties; Magnetic resonance; magnetic resonance electrical properties tomography (MREPT); Male; Metastases; Middle Aged; Mucosa; Neoplasm Staging; Permittivity; relative permittivity; Statistical analysis; Statistical significance; Surgery; Temperature; Tissues; tumor stage; colorectal cancer; conductivity; relative permittivity; magnetic resonance electrical properties tomography (MREPT); tumor stage
• ISSN: 0197-8462; 1521-186X
• DOI: 10.1002/bem.22066

The study was designed to identify differences in the dielectric properties of ex vivo colorectal cancerous tissues at different tumor stages. To date, 130 freshly excised colorectal cancerous specimens underwent measurement of both relative permittivity and conductivity on the serosal and mucosal surfaces of the carcinoma nidus, and the mucosa of the surgical resection margin ranging from 50 to 500 MHz at the Larmor frequencies. Tumor node metastasis staging was determined according to pathological reports for each patient. There were statistically significant differences in the relative permittivity of both colorectal cancerous serosa and mucosa among stages ≤I, II, III, and IV and between stages ≤II and ≥III (P < 0.05) at most frequencies under 300 MHz; statistically significant differences in conductivity were also observed for most of the measured frequencies (P < 0.05). The significant differences in dielectric characteristics among tumor stages, especially between early and advanced stages, have value for selecting appropriate surgical strategies. The presented ex vivo data provide important information for magnetic resonance electrical properties tomography in vivo system because the frequencies of 64 MHz (1.5T) and 128 MHz (3T) are usually used in clinical settings. Bioelectromagnetics. 38:522–532, 2017. © 2017 Wiley Periodicals, Inc.