Tissue engineering of vascular conduits

Background: Autologous conduits are not available in up to 40 per cent of patients with arteriopathy who require coronary or lower limb revascularization, and access sites for renal dialysis may eventually become exhausted. Synthetic prostheses achieve a poor patency rate in small‐calibre anastomose...

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Published in:British journal of surgery Vol. 93; no. 6; pp. 652 - 661
Main Authors: Yow, K.-H., Ingram, J., Korossis, S. A., Ingham, E., Homer-Vanniasinkam, S.
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-06-2006
Wiley
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Summary:Background: Autologous conduits are not available in up to 40 per cent of patients with arteriopathy who require coronary or lower limb revascularization, and access sites for renal dialysis may eventually become exhausted. Synthetic prostheses achieve a poor patency rate in small‐calibre anastomoses. This review examines how vascular tissue engineering may be used to address these issues. Methods: A Medline search was performed, using the keywords ‘vascular tissue engineering’, ‘small diameter vascular conduit’, ‘vascular cell biology’, ‘biomechanics’, ‘cell seeding’ and ‘graft endothelialization’. Key references were hand‐searched for relevant papers. Results and conclusion: In vitro and in vivo approaches are currently being used for guided cell repopulation of both biological and synthetic scaffolds. The major clinical problem has been extended culture time (approximately 6 weeks), which precludes their use in the acute setting. However, recent advances have led not only to improved patency rates for prostheses, but also to a potential reduction in culture time. In addition, increased mobilization of endothelial progenitor cells in the presence of ischaemic tissue may increase the autologous cell yield for scaffold reseeding with further reduction in culture time. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Not yet clinically applicable
Bibliography:Academic Research Fund, Vascular Surgical Unit, Leeds General Infirmary
istex:E3510E6CDF803E07994504BDB4BF0DC4C9B3E238
ark:/67375/WNG-CD4X63F2-2
ArticleID:BJS5343
York NHS Trust
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Article-2
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ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5343