Three-dimensional tumor perfusion reconstruction using fractal interpolation functions

• Published in: IEEE transactions on biomedical engineering Vol. 48; no. 4; pp. 462 - 473
• Main Authors: Craciunescu, O.I., Das, S.K., Poulson, J.M., Samulski, T.V.
• Format: Journal Article
• Language: English
• Published: New York, NY IEEE 01-04-2001; Institute of Electrical and Electronics Engineers; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Animals; Biological and medical sciences; Blood; Contrast Media; Dogs; Equations; Fibrosarcoma - blood supply; Forelimb; Fractals; General aspects; Image Processing, Computer-Assisted - methods; Image reconstruction; Interpolation; Magnetic Resonance Imaging; Medical sciences; Models, Cardiovascular; Neoplasms; Polynomials; Spline; Tumors; Two dimensional displays; Fissipedia; Carnivora; Tumoral tissue; Fractal system; Metabolism; Nuclear magnetic resonance imaging; Modeling; Image reconstruction; Interpolation; Vertebrata; Mammalia; Three dimensional representation; Perfusion; Animal; Medical imagery; Circulatory system; Hemodynamics; Dog
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/10.915713

It has been shown that the perfusion of blood in tumor tissue can be approximated using the relative perfusion index determined from dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool. Also, it was concluded in a previous report that the blood perfusion in a two-dimensional (2-D) tumor vessel network has a fractal structure and that the evolution of the perfusion front can be characterized using invasion percolation. Here, the three-dimensional (3-D) tumor perfusion is reconstructed from the 2-D slices using the method of fractal interpolation functions (FIF), i.e., the piecewise self-affine fractal interpolation model (PSAFIM) and the piecewise hidden variable fractal interpolation model (PHVFIM). The fractal models are compared to classical interpolatlon techniques (linear, spline, polynomial) by means of determining the 2-D fractal dimension of the reconstructed slices. Using FIFs instead of classical interpolation techniques better conserves the fractal-like structure of the perfusion data. Among the two FIF methods, PHVFIM conserves the 3-D fractality better due to the cross correlation that exists between the data in the 2-D slices and the data along the reconstructed direction. The 3-D structures resulting from PHVFIM have a fractal dimension within 3%-5% of the one reported in literature for 3-D percolation. It is, thus, concluded that the reconstructed 3-D perfusion has a percolation-like scaling. As the perfusion term from bio-heat equation is possibly better described by reconstruction via fractal interpolation, a more suitable computation of the temperature field induced during hyperthermia treatments is expected.