Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times

The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of deat...

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Published in:The American journal of cardiology Vol. 94; no. 9; pp. 1166 - 1168
Main Authors: Saab, Fadi A., Eagle, Kim A., Kline-Rogers, Eva, Fang, Jianming, Otten, Richard, Mukherjee, Debabrata
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-11-2004
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Abstract The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome.
AbstractList The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome.
The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins &lt;24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome.
The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome. [PUBLICATION ABSTRACT]
Author Mukherjee, Debabrata
Otten, Richard
Fang, Jianming
Eagle, Kim A.
Saab, Fadi A.
Kline-Rogers, Eva
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  givenname: Eva
  surname: Kline-Rogers
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  surname: Otten
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  givenname: Debabrata
  surname: Mukherjee
  fullname: Mukherjee, Debabrata
  email: dmukherj@umich.edu
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10.1001/jama.287.23.3087
10.1161/01.CIR.0000047060.60595.CC
10.1161/01.CIR.0000037106.76139.53
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Issue 9
Keywords Human
Prognosis
Onset time
Acute
Cardiovascular disease
Evolution
Statin derivative
Coronary heart disease
Comparative study
Language English
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Snippet The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well...
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SubjectTerms Adrenergic beta-Antagonists - therapeutic use
Aged
Angina, Unstable - drug therapy
Angina, Unstable - mortality
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Clinical outcomes
Comparative analysis
Coronary Disease - drug therapy
Coronary Disease - mortality
Coronary heart disease
Female
Follow-Up Studies
Heart
Heart attacks
Hospital Mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Medical sciences
Michigan
Middle Aged
Multivariate Analysis
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Pharmaceuticals
Studies
Syndrome
Time Factors
Treatment Outcome
Title Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times
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