Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times
The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of deat...
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Published in: | The American journal of cardiology Vol. 94; no. 9; pp. 1166 - 1168 |
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01-11-2004
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Abstract | The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome. |
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AbstractList | The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome. The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome. The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome. [PUBLICATION ABSTRACT] |
Author | Mukherjee, Debabrata Otten, Richard Fang, Jianming Eagle, Kim A. Saab, Fadi A. Kline-Rogers, Eva |
Author_xml | – sequence: 1 givenname: Fadi A. surname: Saab fullname: Saab, Fadi A. – sequence: 2 givenname: Kim A. surname: Eagle fullname: Eagle, Kim A. – sequence: 3 givenname: Eva surname: Kline-Rogers fullname: Kline-Rogers, Eva – sequence: 4 givenname: Jianming surname: Fang fullname: Fang, Jianming – sequence: 5 givenname: Richard surname: Otten fullname: Otten, Richard – sequence: 6 givenname: Debabrata surname: Mukherjee fullname: Mukherjee, Debabrata email: dmukherj@umich.edu |
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Cites_doi | 10.7326/0003-4819-140-11-200406010-00006 10.1001/jama.285.13.1711 10.1016/j.amjmed.2004.02.006 10.1001/jama.287.23.3087 10.1161/01.CIR.0000047060.60595.CC 10.1161/01.CIR.0000037106.76139.53 |
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Keywords | Human Prognosis Onset time Acute Cardiovascular disease Evolution Statin derivative Coronary heart disease Comparative study |
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References | Newby, Kristinsson, Bhapkar, Aylward, Dimas, Klein, McGuire, Moliterno, Verheugt, Weaver, Califf (bib1) 2002; 287 Braunwald, Antman, Beasley, Califf, Cheitlin, Hochman, Jones, Kereiakes, Kupersmith, Levin (bib5) 2002; 106 Lau, Waskell, Watkins, Neer, Horowitz, Hopp, Tait, Carville, Guyer, Bates (bib6) 2003; 107 Schwartz, Olsson, Ezekowitz, Ganz, Oliver, Waters, Zeiher, Chaitman, Leslie, Stern (bib2) 2001; 285 Libby, Ridker (bib3) 2004; 116 Spencer, Allegrone, Goldberg, Gore, Fox, Granger, Mehta, Brieger (bib4) 2004; 140 Spencer (10.1016/j.amjcard.2004.07.085_bib4) 2004; 140 Braunwald (10.1016/j.amjcard.2004.07.085_bib5) 2002; 106 Libby (10.1016/j.amjcard.2004.07.085_bib3) 2004; 116 Schwartz (10.1016/j.amjcard.2004.07.085_bib2) 2001; 285 Newby (10.1016/j.amjcard.2004.07.085_bib1) 2002; 287 Lau (10.1016/j.amjcard.2004.07.085_bib6) 2003; 107 |
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SubjectTerms | Adrenergic beta-Antagonists - therapeutic use Aged Angina, Unstable - drug therapy Angina, Unstable - mortality Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Clinical outcomes Comparative analysis Coronary Disease - drug therapy Coronary Disease - mortality Coronary heart disease Female Follow-Up Studies Heart Heart attacks Hospital Mortality Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Medical sciences Michigan Middle Aged Multivariate Analysis Myocardial Infarction - drug therapy Myocardial Infarction - mortality Pharmaceuticals Studies Syndrome Time Factors Treatment Outcome |
Title | Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times |
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