Comparison of outcomes in acute coronary syndrome in patients receiving statins within 24 hours of onset versus at later times

• Published in: The American journal of cardiology Vol. 94; no. 9; pp. 1166 - 1168
• Main Authors: Saab, Fadi A., Eagle, Kim A., Kline-Rogers, Eva, Fang, Jianming, Otten, Richard, Mukherjee, Debabrata
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-11-2004; Elsevier; Elsevier Limited
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Aged; Angina, Unstable - drug therapy; Angina, Unstable - mortality; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Clinical outcomes; Comparative analysis; Coronary Disease - drug therapy; Coronary Disease - mortality; Coronary heart disease; Female; Follow-Up Studies; Heart; Heart attacks; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; Medical sciences; Michigan; Middle Aged; Multivariate Analysis; Myocardial Infarction - drug therapy; Myocardial Infarction - mortality; Pharmaceuticals; Studies; Syndrome; Time Factors; Treatment Outcome; Michigan; Human; Prognosis; Onset time; Acute; Cardiovascular disease; Evolution; Statin derivative; Coronary heart disease; Comparative study
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2004.07.085

The clinical benefits of statins in acute coronary syndromes are well established, but the optimal time for administration in this setting has not been well studied. In this study, patients who had acute coronary syndrome and received statins <24 hours of presentation had lower incidences of death, stroke, reinfarction, heart failure, and pulmonary edema compared with delayed administration. Prompt administration of statins appears to be significantly beneficial in patients who present with an acute coronary syndrome.