Alu transposable elements rewire enhancer-promoter network through RNA pairing

A recent study by Liang et al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity f...

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Bibliographic Details
Published in:	Molecular cell Vol. 83; no. 18; pp. 3234 - 3235
Main Authors:	Wen, Xingzhao, Zhong, Sheng
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 21-09-2023
Subjects:	Alu Elements - genetics DNA Transposable Elements - genetics Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid RNA, Antisense
Online Access:	Get full text
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Summary:	A recent study by Liang et al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity for eRNA-uaRNA pairing and hence enhancer-promoter recognition. A recent study by Liang et al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity for eRNA-uaRNA pairing and hence enhancer-promoter recognition.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-2765 1097-4164 1097-4164
DOI:	10.1016/j.molcel.2023.08.026