Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases

• Published in: Frontiers in pediatrics Vol. 11; p. 1191651
• Main Authors: Yang, Yi-Kang, Lin, Fen, Lin, Jian-Feng, Lin, Chun-Fan, Liu, Li-Li, Ma, Yu-Bin, Wang, Xian-Yao, Liao, Yu-Wei, Huang, Yu-Chan, Zeng, Guang-Kuan, Xiao, Bei-Ru, Huang, Shan-Hua, Xu, Yu-Mei, Chen, Yue-E, Cao, Yan-Bin, Yang, Li-Ye
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20-06-2023
• Subjects: China; COVID-19; neonate; omicron; Pediatrics; prognosis; SARS-CoV-2; COVID-19; SARS-CoV-2; neonate; omicron; prognosis; China
• ISSN: 2296-2360; 2296-2360
• DOI: 10.3389/fped.2023.1191651

To analyze the clinical characteristics of neonatal infection during the outbreak of COVID-19 omicron variant in Guangdong province of China.
The clinical data of neonates infected with COVID-19 omicron variant were collected from three hospitals of Guangdong province, their epidemiological history, clinical manifestation and prognosis were summarized.
From December 12, 2022 to January 15, 2023, a total of 52 neonates with COVID-19 infection were identified across three hospitals in Guangdong Province, including 34 males and 18 females. The age of diagnosis was 18.42 ± 6.32 days. 24 cases had clear contact history with adults who were suspected to be infected with COVID-19. The most common clinical manifestation was fever (43/52, 82.7%), the duration of fever was 1-8 days. The other clinical manifestations were cough (27/52, 51.9%), rales (21/52, 40.4%), nasal congestion (10/52, 19.2%), shortness of breath (2/52, 3.8%), and vomiting (4/52, 7.7%). C-reactive protein was only increased in 3 cases. Chest radiological examination was performed in 42 neonates, twenty-three cases showed abnormal chest radiographic findings, including ground-glass opacity and consolidation. Fifty cases were admitted with COVID-19 presentation, two cases were admitted for jaundice. The hospital stay was 6.59 ± 2.77 days. The clinical classification included 3 cases of severe COVID-19 and one critical case. Fifty-one cases were cured and discharged after general treatment, and one critical case with respiratory failure was intubated and transferred to another hospital.
The COVID-19 omicron variant infection in neonates is usually mild. The clinical manifestation and laboratory results are not specific, and the short-term prognosis is good.