BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

• Published in: Phytochemistry reviews Vol. 17; no. 2; pp. 291 - 326
• Main Authors: Dudnik, Alexey, Almeida, A. Filipa, Andrade, Ricardo, Avila, Barbara, Bañados, Pilar, Barbay, Diane, Bassard, Jean-Etienne, Benkoulouche, Mounir, Bott, Michael, Braga, Adelaide, Breitel, Dario, Brennan, Rex, Bulteau, Laurent, Chanforan, Celine, Costa, Inês, Costa, Rafael S., Doostmohammadi, Mahdi, Faria, Nuno, Feng, Chengyong, Fernandes, Armando, Ferreira, Patrícia, Ferro, Roberto, Foito, Alexandre, Freitag, Sabine, Garcia, Gonçalo, Gaspar, Paula, Godinho-Pereira, Joana, Hamberger, Björn, Hartmann, András, Heider, Harald, Jardim, Carolina, Julien-Laferriere, Alice, Kallscheuer, Nicolai, Kerbe, Wolfgang, Kuipers, Oscar P., Li, Shanshan, Love, Nicola, Marchetti-Spaccamela, Alberto, Marienhagen, Jan, Martin, Cathie, Mary, Arnaud, Mazurek, Vincent, Meinhart, Camillo, Sevillano, David Méndez, Menezes, Regina, Naesby, Michael, Nørholm, Morten H. H., Okkels, Finn T., Oliveira, Joana, Ottens, Marcel, Parrot, Delphine, Pei, Lei, Rocha, I., Rosado-Ramos, Rita, Rousseau, Caroline, Sagot, Marie-France, Santos, Claudia Nunes dos, Schmidt, Markus, Shelenga, Tatiana, Shepherd, Louise, Silva, Rita M., Silva, Marcelo Henriques da, Stahlhut, Steen Gustav, Simon, Olivier, Solopova, Ana, Sorokin, Artem, Stewart, Derek, Stougie, Leen, Su, Shang, Thole, Vera, Tikhonova, Olga, Trick, Martin, Vain, Philippe, Veríssimo, André, Vila-Santa, Ana, Vinga, Susana, Vogt, Michael, Wang, Liangsheng, Wang, Lijin, Wei, Wei, Youssef, Sandra, Neves, Ana Rute, Forster, Jochen
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Nature 01-04-2018; Springer Netherlands; Springer Nature B.V; Springer Verlag
• Subjects: Bacteria; Berries; Biochemistry; Biological activity; Biomedical and Life Sciences; Bioprospecting; Chemistry/Food Science; Commercialization; Economic analysis; Fermentation; Fruits; Life Sciences; Microbial cell factories; Optimization; Organic Chemistry; Other; Phenolic compounds; Phenols; Plant Genetics and Genomics; Plant Sciences; Polyphenols; Quantitative Methods; Science & Technology; Sustainable production; Polyphenols; Sustainable production; Bioprospecting; Berries; Microbial cell factories
• ISSN: 1568-7767; 1572-980X
• DOI: 10.1007/s11101-017-9532-2

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
The authors would like to thank the European Union’s Seventh Framework Programme (BacHBerry, Project No. FP7-613793, and FP7-PEOPLE2013-COFUND, Project No. FP7-609405) for the financial support. AD, RF, MHHN, PG, SGS, and JF would also like to acknowledge the Novo Nordisk Foundation. We express our gratitude to Dr. Martha Cyert (Stanford School of Medicine, EUA), Dr. Hitoshi Shimoi (National Research Institute of Brewing, Japan) and Dr. Yoshio Araki (Graduate School of Biosphere Science, Hiroshima University, Japan) for providing the yeast strain YAA5. We also thank Dr. Ian Macraedie, RMIT University, Australia) for providing the plasmid p416_GPDprGFP-A42.