Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer

• Published in: Periodontology 2000
• Main Authors: Belibasakis, Georgios N, Senevirantne, Chaminda Jayampath, Jayasinghe, Ruwan Duminda, Vo, Phuc Thi-Duy, Bostanci, Nagihan, Choi, Youngnim
• Format: Journal Article
• Language: English
• Published: Denmark 19-03-2024
• Subjects: Medicin och hälsovetenskap; oral medicine; mycobiome; oral dysplasia; oral mucosa; oral pathology; oral candidiasis; bacteriome; microbiome; oral cancer; dysbiosis
• ISSN: 0906-6713; 1600-0757; 1600-0757
• DOI: 10.1111/prd.12558

It has long been considered that the oral microbiome is tightly connected to oral health and that dysbiotic changes can be detrimental to the occurrence and progression of dysplastic oral mucosal lesions or oral cancer. Improved understanding of the concepts of microbial dysbiosis together with advances in high-throughput molecular sequencing of these pathologies have charted in greater microbiological detail the nature of their clinical state. This review discusses the bacteriome and mycobiome associated with oral mucosal lesions, oral candidiasis, and oral squamous cell carcinoma, aiming to delineate the information available to date in pursuit of advancing diagnostic and prognostic utilities for oral medicine.