Synthesis of Self-Complementary Betainic Guanine Model Compounds

Synthesis of Self-Complementary Betainic Guanine Model Compounds

Reaction of 4-(dimethylamino)pyridine and 1-methylimid-azole, respectively, on 2-amino-4-chloro-6-hydroxypyrimidine resulted in the formation of pyrimidine-heteroarenium salts. These could be deprotonated using anion exchange resin to yield pyridinium-pyrimidinolates as model compounds for biologica...

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Bibliographic Details
Published in:Chemistry letters Vol. 30; no. 4; pp. 348 - 349
Main Authors: Schmidt, Andreas, Kindermann, Markus Karl
Format: Journal Article
Language:English
Published: Tokyo The Chemical Society of Japan 01-04-2001
Chemical Society of Japan
Online Access:Get full text
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Summary:Reaction of 4-(dimethylamino)pyridine and 1-methylimid-azole, respectively, on 2-amino-4-chloro-6-hydroxypyrimidine resulted in the formation of pyrimidine-heteroarenium salts. These could be deprotonated using anion exchange resin to yield pyridinium-pyrimidinolates as model compounds for biologically highly important betainic guanines present in RNA. As proved by ESIMS, these cross-conjugated mesomeric betaines are self-complementary and form homo-intermolecular dimers.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2001.348