Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

• Published in: The Lancet (British edition) Vol. 363; no. 9417; pp. 1285 - 1286
• Main Authors: Chiu, CH, Su, LH, Chu, C, Chia, JH, Wu, TL, Lin, TY, Lee, YS, Ou, JT
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 17-04-2004; Lancet; Elsevier Limited
• Subjects: Biological and medical sciences; Ceftriaxone - pharmacology; Ciprofloxacin - pharmacology; Deoxyribonucleic acid; DNA; Drug Resistance, Bacterial; E coli; General aspects; Genes; Genes, Bacterial - genetics; Humans; Infections; Male; Medical sciences; Medical treatment; Microbial Sensitivity Tests; Middle Aged; Plasmids; Public health; Salmonella; Salmonella enterica - drug effects; Salmonella enterica - genetics; Salmonella enterica - isolation & purification; Salmonella Infections - drug therapy; Salmonella Infections - microbiology; Sepsis - microbiology; Serotyping; Translocation; Medicine; Cephalosporin derivatives; Antibiotic; Typing; β-Lactams; Salmonella choleraesuis; Bacteria; Isolation; Ceftriaxone; Serotype; Antibacterial agent; Enterobacteriaceae
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(04)16003-0

Salmonella enterica serotype choleraesuis (
S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of
S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in
gyrA and
parC, whereas the
ampC gene (
bla
CMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into
finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant
S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.