Telmisartan or Valsartan Alone or in Combination with Hydrochlorothiazide: A Review

• Published in: Clinical and experimental hypertension (1993) Vol. 35; no. 1; pp. 50 - 60
• Main Author: Lacourcière, Yves
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01-01-2013; Taylor & Francis
• Subjects: Angiotensin II Type 1 Receptor Blockers - administration & dosage; angiotensin receptor blockers; antihypertensive agents; Antihypertensive Agents - administration & dosage; Benzimidazoles - administration & dosage; Benzoates - administration & dosage; blood pressure; Blood Pressure - drug effects; clinical trials; Diuretics - administration & dosage; Drug Combinations; Humans; Hydrochlorothiazide - administration & dosage; Hypertension - drug therapy; Hypertension - physiopathology; Randomized Controlled Trials as Topic; telmisartan; Tetrazoles - administration & dosage; Valine - administration & dosage; Valine - analogs & derivatives; Valsartan
• ISSN: 1064-1963; 1525-6006
• DOI: 10.3109/10641963.2012.690468

The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, all studies with blood pressure reduction as primary endpoint showed significantly greater reductions with telmisartan than with valsartan. Other studies showed that telmisartan was associated with greater improvements in metabolic measures and inflammatory markers than valsartan. These findings suggest that pharmacologic differences between telmisartan and valsartan may translate into clinically relevant differences between the two drugs in the management of hypertension.