Evaluation of food effect on the oral bioavailability of pradigastat, a diacylglycerol acyltransferase 1 inhibitor

• Published in: Biopharmaceutics & drug disposition Vol. 36; no. 7; pp. 452 - 461
• Main Authors: Ayalasomayajula, Surya P., Meyers, Charles D., Yu, Jing, Kagan, Mark, Matott, Ralph, Pal, Parasar, Majumdar, Tapan, Su, Zhenzhong, Crissey, Anne, Rebello, Sam, Sunkara, Gangadhar, Chen, Jin
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-10-2015; Wiley Subscription Services, Inc
• Subjects: Acetates - administration & dosage; Acetates - blood; Administration, Oral; Adolescent; Adult; Aminopyridines - administration & dosage; Aminopyridines - blood; bioavailability; Biological Availability; Diacylglycerol O-Acyltransferase - antagonists & inhibitors; Diacylglycerol O-Acyltransferase - blood; Diet, High-Fat - methods; Dietary Fats - blood; Dose-Response Relationship, Drug; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - blood; Fasting - metabolism; food effect; Food-Drug Interactions - physiology; Humans; Middle Aged; pharmacokinetics; pradigastat; Young Adult; pharmacokinetics; food effect; bioavailability; pradigastat
• ISSN: 0142-2782; 1099-081X
• DOI: 10.1002/bdd.1958

Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results of two studies that evaluated the effect of food on the oral bioavailability of pradigastat using randomized, open‐label, parallel group designs in healthy subjects (n = 24/treatment/study) are presented. In study 1, a single dose of 20 mg pradigastat was administered under the fasted condition or with a high‐fat meal. In study 2, a single dose of 40 mg pradigastat was administered under the fasted condition or with a low‐ or high‐fat meal. At the 20 mg dose, the pradigastat Cmax and AUClast increased by 38% and 41%, respectively, with a high‐fat meal. When 40 mg pradigastat was administered with a low‐fat meal, the Cmax and AUClast increased by 8% and 18%, respectively, whereas with a high‐fat meal the increase was 20% and 18%, respectively. The population pharmacokinetic analysis with the pooled data from 13 studies indicated that administration of pradigastat with a meal resulted in an increase of 30% in both the Cmax and AUC parameters. Based on these results, food overall increased pradigastat exposure in the range of less than 40%, which is not considered clinically significant. Both 20 and 40 mg doses of pradigastat were well tolerated under fasted or fed conditions. Copyright © 2015 John Wiley & Sons, Ltd.