Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susc...

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Bibliographic Details
Published in:	Journal of virology Vol. 89; no. 14; pp. 7409 - 7413
Main Authors:	Negrotto, Soledad, Mena, Hebe A, Ure, Agustin E, Jaquenod De Giusti, Carolina, Bollati-Fogolín, Mariela, Vermeulen, Elba M, Schattner, Mirta, Gómez, Ricardo M
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-07-2015
Subjects:	Arenavirus Cell Differentiation Cell Survival Cellular Response to Infection Cytokines - biosynthesis Dendritic Cells - immunology Dendritic Cells - virology Humans Junin virus Junin virus - immunology Junin virus - pathogenicity
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Summary:	The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Citation Negrotto S, Mena HA, Ure AE, Jaquenod De Giusti C, Bollati-Fogolín M, Vermeulen EM, Schattner M, Gómez RM. 2015. Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains. J Virol 89:7409–7413. doi:10.1128/JVI.01014-15.
ISSN:	0022-538X 1098-5514
DOI:	10.1128/JVI.01014-15