Chromosome abnormalities in lymphocytes and fibroblasts of subjects with multiple endocrine neoplasia type 1

• Published in: Cancer genetics and cytogenetics Vol. 52; no. 1; p. 85
• Main Authors: Scappaticci, S, Maraschio, P, del Ciotto, N, Fossati, G S, Zonta, A, Fraccaro, M
• Format: Journal Article
• Language: English
• Published: United States 01-03-1991
• Subjects: Adult; Chromosome Aberrations - genetics; Chromosome Disorders; Chromosome Fragility; Female; Fibroblasts - ultrastructure; Humans; Karyotyping; Lymphocytes - ultrastructure; Male; Middle Aged; Multiple Endocrine Neoplasia - genetics
• ISSN: 0165-4608
• DOI: 10.1016/0165-4608(91)90057-2

A consistent degree of chromosome instability was found in cultured lymphocytes and in fibroblasts derived from skin biopsies of three patients with multiple endocrine neoplasia type 1 (MEN1). In both tissues, there was a significant increase in chromosomal breakage. Dicentrics and tricentrics, rings, translocations, deletions, acentric fragments, and presumptive double minutes were the most frequent abnormalities in lymphocytes. The fibroblasts of two patients had large clones consisting of trisomy 7 and trisomy 18 cells, respectively.