Preventive effect of Lacticaseibacillus paracasei LMT18-32 on Porphyromonas gingivalis induced periodontitis

• Published in: Food science and biotechnology Vol. 33; no. 9; pp. 2161 - 2167
• Main Authors: Choi, Woo Jin, Cho, Seung Kee, Dong, Hye Jin, Kim, Tai Hoon, Soon, Jaejoon, Lee, Hyo Jin, Yoon, Kwang Ho, Kwak, Seongsung, Yun, Jiae
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01-07-2024; Springer Nature B.V; 한국식품과학회
• Subjects: Alveolar bone; Antibacterial activity; Antiinfectives and antibacterials; Bone loss; Bones; Chemistry; Chemistry and Materials Science; Chronic infection; Damage prevention; Food Science; Gene expression; Lacticaseibacillus paracasei; Nutrition; Pathogens; Periodontitis; Porphyromonas gingivalis; Probiotics; Research Article; Teeth; 식품과학; Proinflammatory cytokines; Periodontitis; Tissue destruction; LMT18-32; Porphyromonas gingivalis; Lacticaseibacillus paracasei LMT18-32
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-023-01451-6

Periodontitis is a severe gum infection leading to chronic inflammation in the gums, damage of tissues around teeth, and destruction of alveolar bones.
Porphyromonas gingivalis
is the major causative pathogen that induces periodontitis. Numerous probiotic bacteria are reported to produce antibacterial substances against pathogens especially oral pathogens, and these are proposed as preventive measures for periodontitis. In this study,
Lacticaseibacillus paracasei
LMT18-32 was evaluated and its antibacterial activity against
P. gingivalis,
and antioxidant activity in vitro were established. In addition, when
L. paracasei
LMT18-32 was administered to periodontitis induced mice, it successfully alleviated the alveolar bone loss and suppressed induced expression of proinflammatory and tissue destruction related genes in the gingival tissue. In conclusion,
L. paracasei
LMT18-32 is proposed as a potential probiotics to prevent periodontitis.