Glycine potentiates NMDA responses in rat hippocampal CA1 neurons

• Published in: Neuroscience letters Vol. 100; no. 1-3; p. 237
• Main Authors: Minota, S, Miyazaki, T, Wang, M Y, Read, H L, Dun, N J
• Format: Journal Article
• Language: English
• Published: Ireland 22-05-1989
• Subjects: 2-Amino-5-phosphonovalerate; Action Potentials - drug effects; Animals; Aspartic Acid - analogs & derivatives; Aspartic Acid - pharmacology; Glycine - pharmacology; Hippocampus - drug effects; Hippocampus - physiology; Humans; N-Methylaspartate; Rats; Valine - analogs & derivatives; Valine - pharmacology
• ISSN: 0304-3940
• DOI: 10.1016/0304-3940(89)90691-5

When superfused onto rat hippocampal slices, glycine (0.1-0.5 mM) potentiated the depolarization induced by pressure application of NMDA in normal Krebs solution and the synaptic discharge evoked by stimulation of the Schaffer collateral-commissural inputs to the CA1 pyramidal neurons bathed in Mg2+-free media; the effects were not prevented by strychnine. In addition, glycine partially reversed the blocking effect of D-2-amino-5-phosphonovalerate (AP5) on N-methyl-D-aspartate (NMDA)-induced depolarization. These results show that glycine at relatively high concentrations potentiates the NMDA-mediated response in hippocampal slices.